Drug Discovery Simulation

LEARNING OBJECTIVES

The overall objective of the simulation is for participants to gain understanding of what is needed in the complex drug discovery process. More specifically:

• To understand the drug discovery process and the role of disciplines within the process.
• To experience the interfaces and interactions between the different disciplines.
• To learn about results of actions and decisions to be taken at crucial points in the process.
• To learn to react on deviations and risks in the drug discovery environment.

COURSE DESCRIPTION

The simulation starts with the identification of (novel) biological targets and runs through the target validation process via assay development and screening to identify hits amenable for optimization to leads. Full blown lead optimization results in the proposal of one or more preclinical candidates to the management board.

COURSE FORMATS

LBS is able to offer this course as an face-to-face, in-life course or as an on-line version, that you can take from home.

Day 1

Target identification and validation

MORNING

• Explanation of the simulation
• Preparation in teams
• Introduction target validation
• Output targets and required budgets

AFTERNOON

• Management meeting
• Target validation
• Assay development

EVENING

• High throughput screening
• Scientific review meeting
• Evaluation

Day 2

Lead  identification

MORNING

• Introduction hit to lead optimization
• Hit optimization
• Lead candidate proposal

AFTERNOON

• Target Product Profile and flow charts
• Scientific review meeting
• Molecular design experiment

EVENING

• Lead optimization plan
• Evaluation
• Social event